Toxic and metabolic disorders

Primary Toxic-Metabolic encephalopathy

Secondary toxic-metabolic encephalopathy

  • Primary gray matter lesions
    • Wernicke's encephalopathy (Wernicke's disease)
    • Carbon monoxide poisoning
  • Primary white matter lesions
    • Central Pontine Myelinolysis
    • Extrapontine myelinolysis (Osmotic demyelination syndrome)
    • Marchiafava–Bignami disease
    • Subacute Combined Degeneration of the spinal cord (Funicular myelosis)
    • Treatment-induced leukoencephalopathy
      • Chemotherapy-induced toxic leukoencephalopathy
      • Radiation necrosis (Radiation-induced leukoencephalopathy)
  • Both white and gray matter lesions
    • Manganese intoxication
    • Carbon monoxide poisoning
    • Solvent neurotoxicity
    • CNS drug addiction
  • Limbic encephalitis